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What is the first sign of MgSo4 Toxicity & what is antidote for it?

 

Loss of deep tendon reflexes are earliest sign of magnesium toxicity.

other toxicity efffects:

  • decrease respiratory rate
  • decrease urinary output

Antidote is calcium gluconate.

Point to remember: MgSo4 is used in preeclampsia & level should be maintain 4-7 meq/L.

8-10 meq/L level can stop uterine contraction.

more than 12 meq/L can cause death by respiraty paralysis.

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