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Disseminated Intravascular Coagulation (DIC): Presentation,Diagnosis & Treatment

(HIGH YIELD NOTES FOR |MBBS|NEETPG|NEXT|INICET|FMGE)

 

DIC is characterized by both thrombosis and hemorrhage.

It is caused by deposition of fibrin in small blood vessels, leading to thrombosis and end-organ damage. Depletion of clotting factors and platelets leads to a bleeding diathesis.

 

 

Presentation:

Disorders commonly associated with DIC include:

  • obstetric complications
  • infections with septicemia
  • acute promyelocytic leukemia
  • pancreatitis
  • intravascular hemolysis
  • vascular disorders (eg, aortic aneurysm)
  • massive tissue injury and trauma

 

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Diagnosis:

Clotting factors
decrease
PT & aPTT
Increase
Platlets
decrease
D-dimer & fibrin degradation products
Increase
Fibrinogen levels
decrease
Microangiopathic hemolytic anemia
Present

DIC may be confused with severe liver disease, but unlike liver disease, factor VIII is depressed.

 

 

Treatment:

Treat the underlying cause; RBC transfusion, platelet transfusion, and shock management.

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