Which of the following test has maximum sensitivity for diagnosing Pheochromocytoma?
a) MIBG scintigraphy
(b) Somatostatin receptor scintigraphy
(c) Fluro-DOPA PET scan
(d) 24 hours urinary fractionated metanephrines and catecholamines
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ANS- (d) 24 hours urinary fractionated metanephrines and catecholamines
Urinary tests for metanephrines (total or fractionated) and catecholamines are widely available and are used commonly for initial evaluation. Among these tests, those for the fractionated metanephrines and catecholamines are the most sensitive.