Q117. (INFERTILITY)

117. Antisperm antibodies are usually present in:

(a) Cervix
(b) Vagina
(c) Uterus
(d) Fallopian tube

ANS- (a) Cervix

Antisperm antibodies are usually present in cervix.

Most common variety of antisperm antibodies are IgG, IgM, and IgA isotypes. IgG may be found in cervical mucus, serum, and semen. Agglutinating antibodies of IgA class are found in cervical mucus and seminal plasma. The IgM (larger) molecules are found exclusively in the serum. These immunoglobulins can bind to different parts of the sperm (e.g. head, body, or tail) and make them immobile.

Detection of antisperm antibody has not been found to be helpful in the management of infertility. Treatment of antisperm antibodies has not improved the pregnancy outcome.

In the presence of antisperm antibodies in the cervical mucus, dexamethasone 0.5 mg at bed time in the follicular phase may be given. As there is no distinct benefit of such treatment in antisperm antibody positive patients.

Currently intrauterineminsemination (lUI) is the choice of treatment for such cases.

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