A young male comes to the OPD with history of jaundice since many years. He has noted that the jaundice may fluctuate but is often aggravated when he is fasting. There is no history of hospitalisation, no drug use, alcoholism or blood transfusion. Family history is not significant. Clinical examination is unremarkable except for mild scleral icterus. What is the likely diagnosis?

(a) Dubin Johnson syndrome
(b) Crigler Najjar syndrome type-I
(c) Gilbert’s syndrome
(d) Rotor syndrome

ANS- (c) Gilbert’s syndrome

Gilbert syndrome is autosomal recessive defect in which bilirubin entry into hepatocyte affected.

Mostly patient asymptomatic & present with recurrent jaundice  & morning or fasting hypoglycemia.


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