A 50-year-old lady with thyroid swelling underwent total thyroidectomy. The gross specimen and histopathological slide is shown below. Diagnosis is: (NEXT Pattern)
a. Medullary carcinoma of thyroid
b. Hashimoto thyroiditis
c. Follicular carcinoma
d. Anaplastic carcinoma
Ans. (a) Medullary carcinoma of thyroid
‘The following features in the image point to the diagnosis of medullary carcinoma of thyroid.
The cut surface of gland shows multiple tumor areas with areas of hemorrhage. The tumor is yellow to white.
The tumor cells are separated by amyloid stroma (eosinophilic deposits). This stroma is derived from calcitonin. Their pattern gives it a glomeruloid configuration.