Toxoplasma gondii


Toxoplasma gondii: (tachyzoite)


Disease:

Immunocompetent:

mononucleosis-like symptoms, ⊝ heterophile antibody test
Reactivation in AIDS Ž brain abscesses usually seen as multiple ring-enhancing lesions on MRI

Congenital toxoplasmosis:

classic triad of chorioretinitis, hydrocephalus, and intracranial calcifications


Transmission:

Cysts in meat (most common); oocysts in cat feces; crosses placenta (pregnant
patients should avoid cats)


Treatment :

Sulfadiazine + pyrimethamine
Prophylaxis with TMP-SMX when CD4+ cell count < 100 cells/mm3


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